UN-IGME is led by UNICEF and includes WHO, the World Bank Group and the United Nations Population Division of the Department of Economic and Social Affairs.
12212
完全耐药结核病常见问答
Tuberculosis: Totally drug-resistant TB
12213
2015年6月7日 | 问答
7 June 2015 | Q&A
12214
对术语“完全耐药”的定义是否明确？
Is the term “totally drug resistant” clearlydefined?
12215
它是否得到世卫组织的认可？
Is it recognised by the WHO?
12216
对于结核病尚未明确使用“完全耐药”这类术语。
The term “totally drug resistant” has not been clearly defined for tuberculosis.
While the concept of “total drug resistance” is easily understood in general terms, in practice, in vitro drug susceptibility testing (DST) is technically challenging and limitations on the use of results remain: conventional DST for the drugs that define MDR and XDR-TB has been thoroughly studied and consensus reached on appropriate methods, critical drug concentrations that define resistance, and reliability and reproducibility of testing.
[9] Data on the reproducibility and reliability of DST for the remaining SLDs are either much more limited or have not been established, or the methodology for testing does not exist.
12219
更重要的是，尚未充分建立药敏检测结果与对治疗的临床反应之间的相互关系。
Most importantly, correlation of DST results with clinical response to treatment has not yet been adequately established.
12220
因此，当针对一种结核菌株的体外药敏检测结果显示为耐药时，患者实际上仍有可能对这些药物敏感。
Thus, a strain of TB with in vitro DST results showing resistance could in fact, in the patient, be susceptible to these drugs.