Three major shifts in the pandemic and the operating environment for the ACT Accelerator have necessitated a refresh of ACT Accelerator priorities, financing requirements, and investment case.
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然而，世界继续面临来自COVID-19的前所未有且迅速演变的威胁。
The ACT-Accelerator is well positioned to respond to these challenges.
In 2020, a substantial focus was on developing and evaluating a sound product portfolio by investing in R&D, product assessment, and market shaping, while laying the groundwork for large-scale procurement and in-country delivery.
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首先，COVID-19疫苗现已推出，但面临严重的供应限制。
Now that an initial set of effective and affordable COVID-19 tools is available, resources are increasingly focused on optimizing their public health impact.
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其次，正在出现特征日益令人关切的病毒变体。
In 2021, ACT Accelerator aims to fully leverage these existing tools and available volumes, then expand manufacturing, while continuing to invest in further R&D and product optimization.
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ACT加速计划完全有能力应对这些挑战。
The original ACT-Accelerator investment case published in September 2020 outlined a total requirement of US$ 38.1 billion to fully fund its work.
Based on the refreshed strategic priorities outlined above, the Pillars have adjusted their resource needs.
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现在，一套有效且负担得起的COVID-19工具已经问世，资源正日益集中于优化其对公众健康的影响上。
Despite generous donor contributions amounting to US$ 11.0 billion to date, ACT Accelerator continues to require an additional US$ 22.1 billion in 2021 to deliver on its full promise, and fund its vital work to deliver over 2 billion doses of vaccines, 900 million tests and up to 100 million of new treatment courses.